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  1. Hand-Foot Syndrome: What It Is, Causes & Treatment

    Sep 8, 2022 · Hand-foot syndrome (HFS), or palmar-plantar erythrodysesthesia, is a skin reaction that affects the palms of your hands and the soles of your feet. It’s a common side effect of some types of …

  2. Management of cytotoxic chemotherapy-induced hand-foot syndrome

    Hand-foot syndrome (HFS) is a common skin reaction to systemic therapy that should be anticipated with chemotherapeutic treatments such as pegylated liposomal doxorubicin, docetaxel, and …

  3. What is hand-foot syndrome (Palmar-plantar erythrodysesthesia)?

    Mar 11, 2021 · Hand-foot syndrome (also called palmar-plantar erythrodysesthesia) is a side effect of some chemotherapy drugs that can cause redness, swelling and blistering on the palms of the hands …

  4. Hand-Foot Syndrome - Skin Problems | American Cancer Society

    Hand-foot syndrome can cause redness, swelling, and pain on the palms of the hands and the soles of the feet. Learn what to expect and watch for, and when to get help if your cancer treatment side …

  5. Hand-Foot Syndrome and Hand-Foot Skin Reaction

    Jul 29, 2023 · This information explains what hand-foot syndrome and hand-foot skin reaction are. It also explains how you can manage and treat symptoms.

  6. Hand-Foot Syndrome - Chemocare

    Also called hand-foot syndrome or hand-to-foot syndrome, Palmar-Plantar Erythrodysesthesia is a side effect, which can occur with several types of chemotherapy or biologic therapy drugs used to treat …

  7. Hand-foot syndrome - DermNet

    The hand-foot syndrome usually first appears within days of commencing chemotherapy, although it may take several months and a number of chemotherapy cycles. The palms are always involved and …

  8. Hand-Foot Syndrome - OncoLink

    Jan 27, 2026 · HFS can start as a feeling of tingling or numbness in the palms and/or soles. It can lead to swelling, redness, peeling skin, and tenderness or pain. Your hands and/or feet can blister, which …

  9. Hand Foot Syndrome - What You Need to Know - Drugs.com

    Feb 4, 2026 · Care guide for Hand Foot Syndrome. Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.

  10. Sep 25, 2025 · Hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR) are both skin toxicities caused by cancer treatments, but they differ in the type of medication, presentation, and timeline. …