Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most ...
Fungi represent a prolific source of structurally complex natural products with diverse pharmacological activities, many of which have been developed into clinical therapeutics or serve as essential ...
Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine ...
This work reveals metabolic pathways and molecular events mechanistically linked to B cell activation. Using an unbiased, comprehensive proteome profiling method and various functional validation ...
Serine functions as a building block for proteins, is involved in cell proliferation, and various metabolic pathways. The researchers found that in mice fed a diet low in serine and glycine, another ...
Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most macrophages fall into the latter camp—dubbed M2-like—fueling tumor ...
The review introduces the molecular subtypes of breast cancer and outlines how altered amino acid metabolism supports tumor growth. It explores key amino acid pathways—including glutamine, serine, ...
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This manuscript investigates how cellular NAD/NADH ratios are ...
Despite the variety of treatments available for acute myeloid leukemia (AML), their therapeutic efficacy remains limited, and the 5-year survival rate is still below 30%. Epigenetic changes, including ...
Pigments and colors play a crucial role in nature, supporting functions such as camouflage, communication, mate attraction, and protection from radiation. Leucophores, which form uric acid crystals, ...
Gas chromatography–mass spectrometry (GC–MS) was used to detect the chemical components of natural musk, harvested from forest musk deer at multiple stages of maturity. This research combines ...
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